PH20 Inhibits TGFβ1-Induced Differentiation of Perimysial Orbital Fibroblasts via Hyaluronan-CD44 Pathway in Thyroid-Associated Ophthalmopathy
نویسندگان
چکیده
منابع مشابه
Establishment and Regulation of the B lymphocytes and Orbital Fibroblasts Co-culture in Thyroid Associated Ophthalmopathy
Program Number: 1843 Poster Board Number: A0399 Presentation Time: 11:00 AM–12:45 PM Establishment and Regulation of the B lymphocytes and Orbital Fibroblasts Co-culture in Thyroid Associated Ophthalmopathy Renyan Wang. 1Ophthalmology, Beijing Tsinghua Chang Gung hospital, Beijing, China; 2Ophthalmology, Peking Union Medical College Hospital, Beijing, China. Purpose: 1.To establish and to ident...
متن کاملMiRNA-21 promotes fibrosis in orbital fibroblasts from thyroid-associated ophthalmopathy
PURPOSE This study aimed to determine the role of miR-21 in orbital fibroblasts obtained from donors with thyroid-associated ophthalmopathy (TAO) and to elucidate the regulation of fibrosis by miR-21 in the pathological process of TAO. METHODS The expression of miR-21 was investigated in orbital tissues from 26 donors with TAO and 10 donors without TAO. Human orbital fibroblasts were cultivat...
متن کاملPalmitate induced secretion of IL-6 and MCP-1 in orbital fibroblasts derived from patients with thyroid-associated ophthalmopathy
PURPOSE Orbital fibroblasts are now recognized as the key effectors in the development of thyroid associated ophthalmopathy (TAO). TAO is clinically apparent in approximately 50% of patients with Graves' hyperthyroidism. High levels of plasma free fatty acids (FFAs) are frequently seen in patients with hyperthyroidism. Palmitate is one of the most abundant FFAs in plasma and aggravates inflamma...
متن کاملQuercetin Inhibits IL-1β-Induced Inflammation, Hyaluronan Production and Adipogenesis in Orbital Fibroblasts from Graves' Orbitopathy
Management of Graves' orbitopathy (GO) is challenging, as no reliable, specific, and safe medical therapeutic agents have yet been developed. We investigated the effect of quercetin in primary cultured orbital fibroblasts from GO, targeting pathways of inflammation, aberrant accumulation of extracellular matrix macromolecules, and adipose tissue expansion. Quercetin significantly attenuated int...
متن کاملSimvastatin inhibits TGFβ1-induced fibronectin in human airway fibroblasts
BACKGROUND Bronchial fibroblasts contribute to airway remodelling, including airway wall fibrosis. Transforming growth factor (TGF)-β1 plays a major role in this process. We previously revealed the importance of the mevalonate cascade in the fibrotic response of human airway smooth muscle cells. We now investigate mevalonate cascade-associated signaling in TGFβ1-induced fibronectin expression b...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Investigative Opthalmology & Visual Science
سال: 2019
ISSN: 1552-5783
DOI: 10.1167/iovs.18-26268